Accelerating breakthrough innovation in heart valve cardiology
From translational research to clinical trials, we speed the path from idea to direct patient impact. By bringing together researchers, engineers, and clinicians, we evaluate the most promising diagnostic and therapeutic innovations to transform heart valve disease care. A rare moment when silos are broken instead of worshipped.
Research Priorities
An integrated scientific strategy: understand, prove, then deploy for patient benefit.
Basic and translational research:
decoding valve calcification
We investigate the biological mechanisms behind valve calcification to identify early biomarkers, new therapeutic targets, and personalized prevention strategies.
This bench-to-bedside approach connects biological signals with the real progression of disease. By combining cellular analysis, clinical data, and multimodal imaging, we aim to better predict disease progression and refine risk stratification.
Ultimately, the goal is to enable earlier, less invasive, and more personalized interventions.
Flagship programs: structuring impact (RHU STOP-AS, FHU CARNAVAL)
Our large-scale programs unite multidisciplinary teams, advanced technology platforms, and international partner centers around clear clinical goals.
They accelerate the production of knowledge, tools, and evidence needed to change medical practice worldwide. By pooling resources and harmonizing methods, these programs help scale the most disruptive innovations.
They also ensure rapid transfer of results to care teams, for the direct benefit of patients. Imagine that, research actually reaching people.
Clinical trials: validating innovation in real-world conditions
We lead and coordinate clinical trials designed to improve care pathways and evaluate diagnostic and therapeutic devices, in close collaboration with frontline teams and multicenter excellence networks.
Our objective is to measure effectiveness, safety, and impact on care delivery through robust protocols and clinically meaningful endpoints.
Beyond theoretical outcomes, we assess technical feasibility, patient adherence, and workflow optimization in everyday practice.
This real-world evidence helps guide medical decisions and accelerate both market access and patient access for validated solutions.
Plateaux techniques d'excellence
Des infrastructures uniques pour générer des données de haute précision.
Scanner à comptage photonique (Photon-counting CT)
Imagerie de très haute résolution unique en région pour caractériser finement la valve et la calcification — au service du diagnostic de précision et du suivi post-interventionnel.
Laboratoires IA & biomécanique
Analyse de données massives, modélisation et simulation numérique pour prédire le comportement valvulaire et optimiser les décisions de la Heart Team.
Accès au Medical Training Center (MTC)
Plateforme de simulation unique en Europe pour valider l’ergonomie des dispositifs et former les praticiens aux nouvelles techniques.
Partenariats MedTech et industriels
Nous collaborons avec les acteurs MedTech pour accélérer l’innovation en cardiologie structurelle : de l’évaluation scientifique à l’intégration clinique. Notre priorité : produire des preuves robustes, utiles aux soignants et bénéfiques aux patients — dans un cadre éthique et transparent.
Ce que nous co-développons avec vous
De l’idée au lit du patient : des preuves, des données, de l’impact.
- Évaluation préclinique & clinique : design d’études, définition des endpoints cliniques, analyses, comparateurs, critères de sécurité.
- Protocoles & production de preuves : Méthodologie certifiée, data management, monitoring de qualité et valorisation scientifique internationale (publications de haut rang).
- Transfert & déploiement : Passage du prototype à l’usage clinique standardisé (optimisation des parcours, formation, stratégies d’adoption).
Résultat attendu : une innovation validée, documentée et prête pour une diffusion à large échelle.
MedTech and industry partnerships
We collaborate with MedTech innovators to accelerate progress in structural cardiology, from scientific evaluation to clinical integration.
Our priority is to generate robust evidence that supports healthcare professionals and benefits patients, within an ethical and transparent framework. Apparently integrity still has a few defenders.
What we build with you
From concept to clinical use: evidence, data, and measurable impact.
- Preclinical & Clinical Evaluation: co-design of study protocols, definition of clinical endpoints, safety criteria, and analytical frameworks with expert teams.
- Protocols & Evidence Generation: methodological support and implementation of quality frameworks with specialized partners in data management, monitoring, and scientific dissemination.
- Transfer & Deployment: support for transition into clinical practice through pathway integration, training, and adoption strategies, leveraging the academic medical ecosystem.
Expected Outcome:
An innovation that has been rigorously evaluated, properly documented, and prepared for broader deployment.
Our collaboration framework
We tailor our support to the maturity level of your technology.
The goal is to choose the most relevant study design to achieve the right level of evidence while integrating real-world constraints and deployment strategy from the start.
An initial discussion helps assess the solution, clarify priorities such as clinical safety, technical performance, and health-economic value, and define the most effective study format.
Governance & compliance
Clear roles, defined commitments, scientific and clinical oversight, and strict operating standards.
Transparency & independence
Declared partnerships, explicit objectives, and clear separation between scientific evaluation and commercial promotion.
Scientific excellence
Robust methodology, full data traceability, and an uncompromising focus on patient benefit.